A heroic crusader (Nicolas Cage) and his close ally (Ron Perlman) return home after decades of fierce fighting to find their world destroyed by the Plague. Believing a witch to be responsible for the devastation, they are commanded by the church Cardinal (Christopher Lee) to transport the girl to a remote monastery where monks will perform an ancient ritual to rid the land of her curse. But they soon discover the girl's dark secret and find themselves battling a powerful and destructive force that will determine the fate of the world forever.