As a young New York couple goes from college romance to marriage and the birth of their first child, the unexpected twists of their journey create reverberations that echo over continents and through lifetimes in Life Itself. Director and writer Dan Fogelman examines the perils and rewards of everyday life in a multigenerational saga featuring an international ensemble including . Set in New York City and Carmona, Spain, Life Itself celebrates the human condition and all of its complications with humor, poignancy and love.